Experimental induction of myelofibrosis with myeloid metaplasia.

Experimental Induction of Myelofibrosis with Myeloid Metaplasia

A LTHOUGH myelofibrosis with myeloid metaplasia ( MMM ) was first described nearly one hundred years ago, the etiology of this disturbance remains uncertain.1 Two interpretations have been offered: first, that there is a primary insult to bone marrow resulting in necrosis and necrobiosis followed by a reparative stage of fibrosis of marrow and compensatory cxtramedullary hematopoiesis in the li...

Thalidomide therapy in compensated and decompensated myelofibrosis with myeloid metaplasia.

Myeloid metaplasia in the gall bladder: a case report.

Idiopathic myelofibrosis is often associated with myeloid metaplasia (extramedullary haemopoiesis) in the spleen and liver. However, the gall bladder is an extremely unusual site for it to occur. A 59 year old man with myelofibrosis, who underwent cholecystectomy for chronic cholecystitis, showed myeloid metaplasia in his gall bladder. Pathologically, this may lead to diagnostic difficulties.

Arthritis due to synovial involvement by extramedullary haematopoiesis in myelofibrosis with myeloid metaplasia.

A 60-year-old man presented with polyarthralgias, a psoriasiform rash, and severe elbow pain. Peripheral blood smear and bone marrow biopsy established a diagnosis of myelofibrosis with myeloid metaplasia. Biopsy of the skin lesions revealed a nonspecific dermatitis. The clinical presentation was inconsistent with psoriatic arthritis, and there was no evidence for associated gout or collagen-va...

Trisomy 13 in a case of myelofibrosis with myeloid metaplasia with early blastic transformation.

We describe a case of early myeloid blastic transformation in a 64-year-old man suffering from myelofibrosis with myeloid metaplasia. Both chronic and blastic phase cytogenetic analysis showed trisomy 13 to be the sole chromosome aberration. A potential role for this rare abnormality in determining such an unusually poor clinical outcome is discussed.